Case Study 5 :      
         
 
Compound 4 is a large protein. The drug is administered today by subcutaneous or intramuscular injection. Physica is developing a formulation of Compound 4 with improved permeability properties with the aim to deliver the drug through the nasal mucosa.
 
         
  Chart 1:

The following chart illustrates how Biodis improved the drug permeability across nasal cells (in vitro model).
 
       
 
Drug concentration in basal chamber of nasal epithelium cell system