Drug Delivery Technologies

Bioavailability Enhancement > Poorly soluble drugs
         
 
Poorly water-soluble (hydrophobic) drug present significant challenges due to their inadequate solubilisation in digestive liquids:

  • Poor bioavailability leading to high dose
  • inter and intra-individual variability leading to inadequate therapy and/or safety concerns
  • Significant food effects on bioavailability


    • Physica Pharma has developed Biodis®, a technology that enables to overcome solubilisation limitations to provide an efficient drug absorption.

    Biodis® technology is based on the application of reactive lipid based carriers enabling to form a thin dispersed system in gastro-intestinal fluids.

    This system maintains the drug in a dissolved state in the physiological milieu and therefore facilitates its absorption through epithelium cells.
     

      Case studies      
             
     

    Physica Pharma currently works on various internal and partnered programs utilizing Biodis® technology to enable the development of novel pharmaceutical products.

    The case studies presented here demonstrate the effectiveness of Biodis® technology on poorly soluble compounds. They illustrate the application of Biodis® to increase drug plasma concentration or to increase drug permeability trough in vitro cells models.