| Drug Delivery Technologies Bioavailability Enhancement > Poorly permeable drugs |
||||||
| Highly water soluble drugs (Class III), while easily soluble in biological liquids, cannot effectively traverse epithelial membranes (composed of lipid layers) and reach the bloodstream. | ||||||
| With Biodis® technology, Physica Pharma offers a solution which addresses the issue of permeability. Biodis® technology is based on the application of reactive lipid based carriers. These carriers bind to the drug in a non-covalent manner thus forming ion-pairs. The new molecular complex is absorbed more efficiently across biological barriers due to its enhanced diffusion properties through lipid layers. |
||||||
Case studies The case studies presented here demonstrate the effectiveness of Biodis® technology on poorly permeable compounds. They illustrate the application of Biodis® to increase drug plasma concentration or to increase drug permeability trough in vitro cells models. |
||||||
 |