Case Study 1 :      
         
 
Physica's Biodis technology was used to develop an oral formulation of, a compound with low water solubility. Physica's goal was to increase the bioavailability of the product.
 
         
  Chart 1:

The following chart illustrates how Biodis improved the drug aqueous solubilisation. 		     
 
Aqueous solubility
Aqueous solubility with Biodis® (enhancement)
0.005 mg/mL
20 mg/mL (4 000)
0.0005 %
2 %
   
         
 

Chart 2:

The following chart illustrates how Biodis improved the drug plasma concentration levels of Coumpond 1 on animal (pigs). The chart compares drug plasma levels of the Biodis product to those of a reference product. 		 
         
 
Mean plasma concentration of Biodis vs. commercial product