SCREENING SYSTEMS

Physica has set up a unique screening system which accelerates the process of formulation selection. This selection method is based on the identification of several physical and biological parameters.

This approach can be applied on compounds resulting from drug discovery and which can benefit from a "physical optimization". It can also be used for molecules in later stages of development or already marketed.

Physical screening system

Physica has developed an efficient "physical" screening tool based on measurements of parameters such as log P, log D, and artificial membrane partition model. This pre-formulation system can be automated and uses only few milligrams of a drug. During this phase, Physica generates data on key compound properties and selects drug delivery agents with the aim to optimise drug's membrane diffusion properties.

Biological screening system

Physica has developed in vitro cell systems which are used to simulate drug transport across biological barriers. Here, the formulation prototypes are screened using biological membranes, thus permitting the detection of the most promising candidates for pre-clinical trials .

Gastrointestinal Absorption

Physica uses a model of the intestinal mucosa based on the human colon carcinoma cell line Caco-2.
These cell culture models allow the permeability and metabolic processes to be examined rapidly under controlled conditions.

Pulmonary absorption

In the same manner, PHYSICA has developed pulmonary cell models based on human pulmonary cell line Calu 3.

Nasal mucosa absorption (contact us for further information)

Dermatological absorption (contact us for further information)